This is why acroosteolysis and periosteal bone formation can be explained by the action of PGE 2.
2.
Since PGE 2 is likely to be involved in periosteal bone formation and acroosteolysis, this is why these drugs can alleviate the polyarthritis associated with PDP . In addition, NSAIDs and corticosteroids decrease formation of inflammatory mediators, reducing inflammation and pain.
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